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KMID : 0359920130320030138
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Korean Journal of Nephrology
2013 Volume.32 No. 3 p.138 ~ p.141
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Two cases of idiopathic membranous nephropathy treated with rituximab
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Yoon Jae-Young
Han Seung-Tae
Cho A-Jin
Jang Hye-Ryoun
Lee Jung-Eun
Huh Woo-Seong
Kim Dae-Joong
Oh Ha-Young
Kim Yoon-Goo
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Abstract
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Idiopathic membranous nephropathy is a common cause of nephrotic syndrome, and has been reported as a cause of idiopathic primary glomerulonephropathy in up to 90% of patients. However, the treatment options remain controversial. We report two cases of idiopathic membranous nephropathy that were treated with rituximab. A 54-yearold man and a 64-year old man were admitted for rituximab therapy. They had previously been treated with combinations of immunosuppressive agents including cyclophosphamide, cyclosporine, mycophenolate, and steroids. However, the patients’ heavy proteinuria was not resolved. Both patients received rituximab therapy, 2 weeks apart. After several months of follow-up and a second round of rituximab treatment for each patient, their proteinuria decreased and partial remission of disease was achieved in both patients.
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KEYWORD
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Idiopathic membranous nephropathy, Nephrotic syndrome, Proteinuria, Rituximab
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